Diabetic kidney disease (DKD) is currently one of the leading causes of end-stage renal disease (ESRD). Mitochondrial dysfunction in podocyte is involve in DKD development. However, whether early mitochondrial stabilization delays or reverses DKD progression has not been elucidated. SS31 is a novel tetrapeptide compound that targets …
Get QuoteSS-20 was the intermediate between SS-02 and SS-31. SS-20 decreased affinity for the μ receptor by 450-fold, while SS-31 decreased affinity by 2,000-fold… virtually ZERO opioid activity despite extremely high doses in mouse studies!. But back to the mitochondria — why is SS-31 such a phenomenal discovery in the world of mitochondrial …
Get QuoteReprinted with permission from [131] SC-TK-SS31 was produced by conjugating SS31 to L-serine-modified chitosan (SC). Chitosan bound to heparin sulfate and glucosamine sulfate in the glomerulus via ...
Get QuoteWhether SS31 can improve pressure-loaded heart failure, and whether SS31 can improve HF through OPA1 also needs further research. As we all know, Sirt3 is a highly conserved nicotinamide adenine dinucleotide (NAD) dependent deacetylase, which plays an important role in regulating cellular stress responses, metabolism, growth and …
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Get Quote: Legion () : SS31-RBIWQ-RD40-LO2-R () : C312616. : . : . : 16.96 (g) : . PDF, …
Get QuoteSepsis also increased diaphragm calpain activity, increased 20S proteasomal activity, decreased MHC levels, reduced mitochondrial function (state 3 rates and ATP generation), and reduced aconitase activity; SS31 prevented each of these sepsis-induced alterations (P ≤ 0.017 for all indices). SS31 prevents sepsis-induced diaphragm …
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Get QuoteSS-31 is a synthetic peptide that improves mitochondrial function and is currently undergoing clinical trials for treatments of heart failure, primary mitochondrial myopathy, and other mitochondrial diseases. SS-31 …
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Get QuoteResults: CsA@PLGA-PEG-SS31 was prepared by nanoprecipitation. CsA@PLGA-PEG-SS31 showed small particle size (~ 50 nm) and positive charge due to the modification of SS31 on the surface of nanoparticles. CsA@PLGA-PEG-SS31 was stable for more than 30 days and displayed a biphasic drug release pattern.
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Get QuoteThe three timepoint scores for the NBT were used to explore the non-cognitive behaviors of mice. At 15 h, the nesting score was lower in APP/PS1 mice than in C57BL/6J mice (P = 0.012), and SS31-treated APP/PS1 mice showed a higher score than untreated APP/PS1 mice (P = 0.036) (Fig. 1 A).At 24 h and 48 h, the nesting scores …
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